Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy

Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, Clinical Variants and Therapy

Acute generalized exanthematous pustulosis (AGEP) is a severe, usually drug-related reaction, characterized by an acute onset of mainly small non-follicular pustules on an erythematous base and spontaneous resolution usually within two weeks. Systemic involvement occurs in about 20% of cases. The course is mostly benign, and only in rare cases complications lead to life-threatening situations. ...

Acute generalized exanthematous pustulosis

Terbinafine-induced acute generalized exanthematous pustulosis.

Terbinafine is an allylamine antifungal agent, effective in the treatment of dermatomycoses. Many cutaneous adverse reactions have been reported (in about 3% of treated patients). Furthermore terbinafine has been associated with pustular eruptions, as well as the induction and exacerbation of pre-existing psoriasis and acute generalized exanthematous pustulosis (AGEP). AGEP is an uncommon asept...

Acute Generalized Exanthematous Pustulosis Associated with Tigecycline

Acute generalized exanthematous pustulosis (AGEP) is a severe and rare eruption that develops mostly from factors related to drugs. It is characterized by a fever and a pustular eruption on the erythematous skin with an acute onset and without follicular localization. Etiopathogenesis has not yet been fully explained. Although it is similar to pustular psoriasis, its clinical, historical and hi...

Acute generalized exanthematous pustulosis with mephenesin balm.

Mephenesin is an aromatic glycerol ether which decreases polysynaptic transmission in the spinal cord and brain stem. It is used as a skeletal muscle relaxant in the treatment of multiple sclerosis, Parkinson’s disease or acute muscle strain [1,2]. Mephenesin is associated to methyl nicotinate in the Décontractyl Balm. The methyl nicotinate has a rubifacient effect. Usually, the Décontractyl Ba...